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KMID : 0377519930180030305
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Chung-Ang Journal of Medicine
1993 Volume.18 No. 3 p.305 ~ p.312
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Activities of Superoxide Dismutase, Catalase and Glutathione Peroxidase in the Ischemic Revascularized Calf Muscles of Rats
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최창영
백광진/이성행/권년수/이희성
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Abstract
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Increased generation of reactive oxygen species is thought to be a major caus of tissue damage in ischemia-reperfusion injury. This study was designed to examine the activities of scavangers of oxygen free radicals, namely, superoxide dismutase
(SOD),
catalase, and glutathione (GSH0 peroxidase, when revascularization was performed after a long period of ischemic time in 30 surgically amputated rat limbs.
@ES The results were as follows:
@EN 1. In the experimental group treated with ischemia or ischemia-reperfusion, activities of catalase were about 2 time higher than those in control group, and the activities in the rats administered with SOD after ischemia were about 6 times
higher
than those in controls.
2. Activities of GSH peroxidase in the experimental groups treated with ischemia were increased significantly, while GSH peroxidase activities in ischemia-reperfusion group were similar to that in controls. SOD-administered group showed higher
GSH
peroxidase activity than control
3. Activities of SOD was decreased in the experimental group treated with ischemia or ischemia-reperfusion.
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KEYWORD
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